Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 7/20 | 0.40 |
| ▸ | BRAF | P15056 | 9/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12237762 | 0.92 | BRAF (0.46) | RIPK2EGFRBRAFKCNH2 | |
| SCHEMBL12670306 | 0.92 | BRAF (0.44) | RIPK2EGFRBRAF | |
| SCHEMBL12669624 | 0.91 | BRAF (0.40) | EGFRBRAF | |
| SCHEMBL1889750 | 0.90 | RIPK2 (0.39) | RIPK2EGFRBRAFKCNH2 | |
| SCHEMBL1869427 | 0.88 | BRAF (0.49) | RIPK2EGFRBRAF | |
| SCHEMBL12668213 | 0.87 | BRAF (0.49) | RIPK2EGFRBRAF | |
| SCHEMBL12670296 | 0.87 | BRAF (0.49) | RIPK2EGFRBRAF | |
| SCHEMBL1870084 | 0.85 | BRAF (0.44) | EGFRBRAF | |
| SCHEMBL1872256 | 0.85 | BRAF (0.40) | BRAF | |
| SCHEMBL2193179 | 0.84 | RIPK2 (0.53) | RIPK2BRAFKCNH2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |