SCHEMBL18688396

SCHEMBL18688396

COc1cc2nccc(Oc3cc(NC(=O)Nc4cccc(N)c4)ccc3C)c2cc1OC

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDGFRA P16234 18/20 0.66
KDR P35968 18/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7483608 0.88 PDGFRA (0.81) PDGFRAKDR
SCHEMBL18687931 0.87 PDGFRA (0.64) PDGFRAKDR
SCHEMBL18687944 0.86 PDGFRA (0.62) PDGFRAKDR
SCHEMBL18687889 0.86 PDGFRA (0.62) PDGFRAKDR
SCHEMBL18688401 0.85 PDGFRA (0.80) PDGFRAKDR
SCHEMBL18687923 0.85 PDGFRA (0.61) PDGFRAKDR
SCHEMBL18687881 0.83 PDGFRA (0.64) PDGFRAKDR
SCHEMBL18688256 0.83 PDGFRA (0.63) PDGFRAKDR
SCHEMBL18687924 0.83 PDGFRA (0.63) PDGFRAKDR
SCHEMBL18688257 0.82 PDGFRA (0.62) PDGFRAKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017049462-A1 NOVEL FLT3 KINASE INHIBITOR AND USES THEREOF 合肥中科普瑞昇生物医药科技有限公司 2017-03-30 WO disclosed