Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1871922 | 0.91 | BRAF (0.37) | BRAFNR1I2 | |
| SCHEMBL12230869 | 0.90 | BRAF (0.40) | BRAFKCNH2NR1I2ACHE | |
| SCHEMBL1871286 | 0.85 | BRAF (0.42) | BRAFNR1I2 | |
| SCHEMBL1877503 | 0.84 | BRAF (0.41) | BRAFNR1I2 | |
| SCHEMBL12230891 | 0.84 | BRAF (0.45) | BRAFKCNH2NR1I2 | |
| SCHEMBL1875091 | 0.84 | BRAF (0.46) | BRAFKCNH2NR1I2ACHE | |
| SCHEMBL1874474 | 0.82 | BRAF (0.45) | BRAFNR1I2 | |
| SCHEMBL1872280 | 0.80 | EGFR (0.38) | BRAFNR1I2 | |
| SCHEMBL12230902 | 0.80 | EGFR (0.43) | BRAFKCNH2NR1I2 | |
| SCHEMBL1866713 | 0.79 | EGFR (0.34) | BRAFNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |