Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.61 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.60 |
| ▸ | IGF1R | P08069 | 5/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.54 |
| ▸ | CCNK | O75909 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CCND3 | P30281 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18696330 | 0.92 | ALK (0.65) | TTKPTK2MAP4K1IGF1RALK | |
| SCHEMBL18696334 | 0.89 | IGF1R (0.57) | TTKPTK2MAP4K1IGF1RALK | |
| SCHEMBL23566973 | 0.86 | EGFR (0.68) | TTKPTK2MAP4K1IGF1RALK | |
| SCHEMBL30736226 | 0.86 | EGFR (0.68) | TTKPTK2MAP4K1IGF1RALK | |
| SCHEMBL17742334 | 0.82 | TTK (0.60) | TTKPTK2MAP4K1IGF1RALK | |
| SCHEMBL15442388 | 0.81 | MAP4K1 (0.55) | TTKPTK2MAP4K1IGF1RALK | |
| SCHEMBL12429374 | 0.79 | PTK2 (0.69) | TTKPTK2IGF1RALK | |
| SCHEMBL18696335 | 0.79 | CCNK (0.79) | IGF1RALKCCNKCCNA2CDK2 | |
| SCHEMBL11919325 | 0.78 | PTK2 (0.84) | PTK2MAP4K1IGF1RALKJAK2 | |
| SCHEMBL29017290 | 0.78 | TTK (0.65) | TTKPTK2MAP4K1IGF1RALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611283-B1 | Methods for inhibiting cell proliferation in ALK-driven cancers | ARIAD PHARMACEUTICALS, INC. (US) | 2017-04-04 | — | — | US | disclosed |