Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 18/20 | 0.90 |
| ▸ | BCR | P11274 | 18/20 | 0.90 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.46 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399576 | 0.94 | ABL1 (1.00) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3397025 | 0.92 | ABL1 (1.00) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3400322 | 0.92 | ABL1 (1.00) | ABL1BCREPHX2 | |
| SCHEMBL3397346 | 0.91 | ABL1 (1.00) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3402594 | 0.89 | ABL1 (0.82) | ABL1BCR | |
| SCHEMBL3400753 | 0.85 | ABL1 (0.72) | ABL1BCR | |
| SCHEMBL3402913 | 0.85 | ABL1 (0.72) | ABL1BCRTTBK1TTBK2EPHX2 | |
| SCHEMBL13820436 | 0.85 | ABL1 (0.72) | ABL1BCRTTBK1TTBK2EPHX2 | |
| SCHEMBL3399079 | 0.85 | ABL1 (0.86) | ABL1BCRTTBK1TTBK2 | |
| SCHEMBL3401465 | 0.84 | ABL1 (0.76) | ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3912973-A2 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | Dana-Farber Cancer Institute, Inc. (US) | 2021-11-24 | — | — | EP | disclosed |
| EP-3536687-B1 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | DANA FARBER CANCER INST INC (US) | 2021-07-14 | — | — | EP | disclosed |
| EP-3536687-A1 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | Dana Farber Cancer Institute, Inc. (US) | 2019-09-11 | — | — | EP | disclosed |
| EP-3150593-A1 | SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE | Dana Farber Cancer Institute, Inc. (US) | 2017-04-05 | — | — | EP | disclosed |