Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 19/20 | 0.71 |
| ▸ | HCRTR2 | O43614 | 13/20 | 0.57 |
| ▸ | CCNK | O75909 | 1/20 | 0.46 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144984 | 1.00 | HCRTR1 (0.71) | HCRTR1HCRTR2CCNKCDK12 | |
| SCHEMBL20144772 | 0.90 | HCRTR1 (0.70) | HCRTR1HCRTR2 | |
| SCHEMBL20144937 | 0.87 | HCRTR1 (0.69) | HCRTR1HCRTR2CCNKCDK12 | |
| SCHEMBL20145105 | 0.87 | HCRTR1 (0.69) | HCRTR1HCRTR2CCNKCDK12 | |
| SCHEMBL20145140 | 0.85 | HCRTR1 (0.60) | HCRTR1HCRTR2 | |
| SCHEMBL20145086 | 0.85 | HCRTR1 (0.60) | HCRTR1HCRTR2 | |
| SCHEMBL16149085 | 0.83 | HCRTR1 (1.00) | HCRTR1HCRTR2 | |
| SCHEMBL20144929 | 0.82 | HCRTR1 (0.72) | HCRTR1HCRTR2CCNKCDK12 | |
| SCHEMBL18697534 | 0.80 | HCRTR1 (0.69) | HCRTR1HCRTR2 | |
| SCHEMBL20144760 | 0.80 | HCRTR1 (0.69) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611251-B2 | Substituted piperidine compounds and their use as orexin receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-04-04 | — | — | US | disclosed |