Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 9/20 | 0.61 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MRGPRX1 | Q96LB2 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSPO | P30536 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1869905 | 1.00 | TLR4 (0.61) | TLR4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1866346 | 0.90 | TLR4 (0.65) | TLR4LMNATP53MRGPRX1KMT2A | |
| SCHEMBL1862533 | 0.90 | TLR4 (0.65) | TLR4LMNATP53MRGPRX1KMT2A | |
| SCHEMBL1866486 | 0.90 | TLR4 (0.65) | TLR4LMNATP53MRGPRX1KMT2A | |
| SCHEMBL1862850 | 0.90 | TLR4 (0.65) | TLR4LMNATP53MRGPRX1KMT2A | |
| SCHEMBL1862992 | 0.90 | TLR4 (0.62) | TLR4LMNATP53MRGPRX1KMT2A | |
| SCHEMBL4159467 | 0.90 | TLR4 (0.48) | TLR4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1864585 | 0.89 | TLR4 (0.63) | TLR4LMNATP53MRGPRX1KMT2A | |
| SCHEMBL1863029 | 0.89 | TLR4 (0.63) | TLR4LMNATP53MRGPRX1KMT2A | |
| SCHEMBL1863576 | 0.88 | TLR4 (0.68) | TLR4LMNAMRGPRX1KMT2ATSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935835-B2 | Substituted cycloalkene derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-05-03 | — | — | US | disclosed |
| EP-1935879-A1 | SUBSTITUTED CYCLOALKENE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2008-06-25 | — | — | EP | disclosed |