⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL427747 | 0.61 | — | — | |
| SCHEMBL11600094 | 0.43 | — | — | |
| SCHEMBL5569414 | 0.43 | — | — | |
| SCHEMBL20542591 | 0.43 | — | — | |
| SCHEMBL1661996 | 0.42 | — | — | |
| SCHEMBL20542540 | 0.42 | — | — | |
| SCHEMBL4362773 | 0.41 | — | — | |
| SCHEMBL5323960 | 0.41 | — | — | |
| SCHEMBL3676194 | 0.41 | — | — | |
| SCHEMBL1876497 | 0.41 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070213316-A1 | Compounds that are effective inhibitors of beta-secretase; inhibitors of beta-secretase-mediated cleavage of amyloid precursor proteins; effective inhibitors of A beta production, and/or are effective to reduce amyloid beta deposits or plaques; treatment of disorders such as Alzheimer's Disease | ELAN PHARMACEUTICALS, INC. | 2007-09-13 | — | — | US | claimed |
| EP-1453789-A2 | N,N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2004-09-08 | — | — | EP | claimed |
| US-20040171881-A1 | N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives | PHARMACIA & UPJOHN COMPANY | 2004-09-02 | — | — | US | claimed |
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | claimed |
| WO-2003040096-A2 | N, N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2003-05-15 | — | — | WO | claimed |
| US-5939493-A | NATURAL RUBBER OR DIENE SYNTHETIC RUBBER, METAL DITHIOPHOSPHATE, TERTIARY AMINE; REINFORCING INORGANIC FILLER | BRIDGESTONE CORPORATION (JP) | 1999-08-17 | — | — | US | claimed |
| EP-0864604-A2 | Rubber composition | Bridgestone Corporation (JP) | 1998-09-16 | — | — | EP | claimed |
| EP-0195374-B1 | N-SUBSTITUTED 3,4-DIHYDROPYRIMIDINE DERIVATIVES, PROCESS FOR THE PRODUCTION THEREOF AND COMPOSITION CONTAINING SAME FOR TREATING DISORDERS OF CARDIOVASCULAR SYSTEM | SUNTORY LIMITED (JP) | 1992-07-29 | — | — | EP | claimed |
| EP-0195374-A2 | N-substituted 3,4-dihydropyrimidine derivatives, process for the production thereof and composition containing same for treating disorders of cardiovascular system | SUNTORY LIMITED (JP) | 1986-09-24 | — | — | EP | claimed |
| US-7939551-B2 | for diabetes mellitus and other metabolic disorders; compounds of given formula such as sulfonamides and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, alpha-glucosidase inhibitors, glucagon antagonists | AMGEN INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-20080255380-A1 | oxidation of the sulfide of a Diels-Alder-protected adducts of C-22 sulfide-derivatives of cholecalciferol and photoisomerization to a sulfone derivatives; chemical intermediates used in the synthesis of pharmacologically-active vitamin D analogs, having a double bond at C-22, such as calcipotriol | INSTYTUT FARMACEUTYCZNY (PL) | 2008-10-16 | — | — | US | disclosed |
| US-7323316-B2 | Glycosyltransferase inhibitors | ABARON BIOSCIENCES, INC. (US) | 2008-01-29 | — | — | US | disclosed |
| EP-1185269-B1 | GLYCOSYLTRANSFERASE INHIBITORS | ABARON BIOSCIENCES INC (US) | 2007-11-14 | — | — | EP | disclosed |
| EP-1756048-A2 | PROCESS AND INTERMEDIATES TO PREPARE THE SULPHONYL DERIVATIVES OF CHOLECALCIFEROL | INSTYTUT FARMACEUTYCZNY (PL) | 2007-02-28 | — | — | EP | disclosed |
| WO-2001082916-A2 | COMBINATION THERAPEUTIC COMPOSITIONS AND METHODS OF USE | TULARIK INC. (US) | 2001-11-08 | — | — | WO | disclosed |
| WO-2001068095-A1 | GLYCOSYLTRANSFERASE INHIBITORS | ABARON BIOSCIENCES, INC. (US) | 2001-09-20 | — | — | WO | disclosed |
| EP-0945488-A2 | Rubber composition | Bridgestone Corporation (JP) | 1999-09-29 | — | — | EP | disclosed |
| US-5939493-A | NATURAL RUBBER OR DIENE SYNTHETIC RUBBER, METAL DITHIOPHOSPHATE, TERTIARY AMINE; REINFORCING INORGANIC FILLER | BRIDGESTONE CORPORATION (JP) | 1999-08-17 | — | — | US | disclosed |
| EP-0864604-A2 | Rubber composition | Bridgestone Corporation (JP) | 1998-09-16 | — | — | EP | disclosed |
| EP-0195374-B1 | N-SUBSTITUTED 3,4-DIHYDROPYRIMIDINE DERIVATIVES, PROCESS FOR THE PRODUCTION THEREOF AND COMPOSITION CONTAINING SAME FOR TREATING DISORDERS OF CARDIOVASCULAR SYSTEM | SUNTORY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |