Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 7/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.38 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1874594 | 0.89 | BRAF (0.43) | BRAFRIPK2KCNH2EGFRLCK | |
| SCHEMBL1875729 | 0.88 | BRAF (0.42) | BRAFRIPK2KCNH2EGFRLCK | |
| SCHEMBL1872504 | 0.87 | BRAF (0.42) | BRAFRIPK2KCNH2EGFRLCK | |
| SCHEMBL1875785 | 0.86 | BRAF (0.40) | BRAFRIPK2KCNH2EGFRLCK | |
| SCHEMBL2196398 | 0.83 | BRAF (0.64) | BRAFRIPK2LCKLYNTGFBR1 | |
| SCHEMBL1866903 | 0.82 | RIPK2 (0.40) | BRAFRIPK2KCNH2EGFRLCK | |
| SCHEMBL2194736 | 0.82 | BRAF (0.53) | BRAFRIPK2KCNH2EGFRLCK | |
| SCHEMBL2194829 | 0.81 | BRAF (0.55) | BRAFRIPK2KCNH2EGFRLCK | |
| SCHEMBL12350507 | 0.80 | BRAF (0.55) | BRAFRIPK2LCKLYNTGFBR1 | |
| SCHEMBL1870361 | 0.80 | RIPK2 (0.40) | BRAFRIPK2KCNH2EGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |