Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.75 |
| ▸ | MEN1 | O00255 | 3/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | JAK2 | O60674 | 1/20 | 0.75 |
| ▸ | NPC1 | O15118 | 2/20 | 0.74 |
| ▸ | RAB9A | P51151 | 1/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | PKM | P14618 | 2/20 | 0.69 |
| ▸ | GCK | P35557 | 1/20 | 0.64 |
| ▸ | GCKR | Q14397 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18886 | 0.86 | MAPT (1.00) | MAPTMEN1KMT2AJAK2NPC1 | |
| SCHEMBL12089243 | 0.85 | MAPT (0.70) | MAPTMEN1KMT2AJAK2NPC1 | |
| SCHEMBL12089501 | 0.84 | MAPT (0.72) | MAPTMEN1KMT2AJAK2NPC1 | |
| SCHEMBL12088871 | 0.83 | GCKR (0.74) | MAPTMEN1KMT2AJAK2NPC1 | |
| SCHEMBL26672755 | 0.81 | NPC1 (0.64) | MAPTMEN1KMT2AJAK2NPC1 | |
| SCHEMBL15462062 | 0.81 | MAPT (0.67) | MAPTMEN1KMT2AJAK2NPC1 | |
| SCHEMBL33152 | 0.80 | GCKR (0.81) | MAPTMEN1KMT2AJAK2MAPK1 | |
| SCHEMBL15854 | 0.80 | GCKR (0.81) | MAPTMEN1KMT2AJAK2MAPK1 | |
| SCHEMBL12078733 | 0.80 | GCKR (0.81) | MAPTMEN1KMT2AJAK2MAPK1 | |
| SCHEMBL1617605 | 0.79 | MAPT (0.69) | MAPTMEN1KMT2AJAK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |