Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MYC | P01106 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18704469 | 1.00 | MAPT (0.67) | MAPTKMT2AKDM4EMEN1PKM | |
| SCHEMBL23719182 | 0.84 | MAPT (0.80) | MAPTKMT2AKDM4EMEN1PKM | |
| SCHEMBL17453569 | 0.83 | MAPT (0.69) | MAPTKMT2AKDM4EMEN1PKM | |
| SCHEMBL18692790 | 0.82 | KDM4E (0.62) | MAPTKMT2AKDM4EMEN1PKM | |
| SCHEMBL18692791 | 0.82 | KDM4E (0.62) | MAPTKMT2AKDM4EMEN1PKM | |
| SCHEMBL12388137 | 0.81 | MAPT (0.72) | MAPTKMT2AKDM4EMEN1HPGD | |
| SCHEMBL12387864 | 0.81 | MAPT (0.76) | MAPTKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL17044411 | 0.81 | GRIN2D (0.59) | MAPTKMT2AKDM4EMEN1PKM | |
| SCHEMBL17044409 | 0.81 | GRIN2D (0.59) | MAPTKMT2AKDM4EMEN1PKM | |
| SCHEMBL12387751 | 0.80 | MAPT (0.71) | MAPTKMT2AKDM4EMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017060873-A1 | SUBSTITUTED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXYLIC ACIDS AND THEIR USE | AbbVie S.à.r.l. (LU) | 2017-04-13 | — | — | WO | disclosed |
| WO-2017060874-A1 | N-SULFONYLATED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE | ABBVIE S.Á.R.L (LU) | 2017-04-13 | — | — | WO | disclosed |