⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18705140 | 0.85 | HRH3 (0.31) | — | |
| SCHEMBL19122487 | 0.83 | — | — | |
| SCHEMBL18705139 | 0.81 | — | — | |
| SCHEMBL20349574 | 0.78 | — | — | |
| SCHEMBL16984140 | 0.73 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL19756431 | 0.73 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL22306023 | 0.73 | — | — | |
| SCHEMBL18705136 | 0.68 | HRH3 (0.36) | — | |
| SCHEMBL19121846 | 0.68 | — | — | |
| SCHEMBL16659520 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023570-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170096425-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2017-04-06 | — | — | US | disclosed |