Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 7/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.32 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.31 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.31 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1869978 | 0.85 | MAP2K1 (0.38) | MAP2K1MAP2K2MAP2K5EIF2AK1CHEK1 | |
| SCHEMBL1867119 | 0.85 | MAP2K1 (0.38) | MAP2K1MAP2K2MAP2K5EIF2AK1CHEK1 | |
| SCHEMBL1867285 | 0.85 | MAP2K1 (0.43) | MAP2K1MAP2K2 | |
| SCHEMBL1870571 | 0.85 | MAP2K1 (0.41) | MAP2K1MAP2K2 | |
| SCHEMBL1868658 | 0.81 | MAP2K1 (0.37) | MAP2K1MAP2K2TRPV1MAP2K5EIF2AK1 | |
| SCHEMBL12669444 | 0.79 | MAP2K1 (0.38) | MAP2K1MAP2K2MAP2K5EIF2AK1MGAT2 | |
| SCHEMBL1866910 | 0.75 | MAP2K1 (0.41) | MAP2K1 | |
| SCHEMBL2280078 | 0.75 | MAP2K1 (0.42) | MAP2K1MAP2K2MGAT2 | |
| SCHEMBL2277649 | 0.74 | MAP2K1 (0.36) | MAP2K1MAP2K2CHEK1MAPK10PRKAG1 | |
| SCHEMBL12095400 | 0.72 | MAP2K1 (0.47) | MAP2K1MAP2K2MAP2K5EIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8466289-B2 | Heterocyclic sulfonamide derivatives | NOVARTIS AG (CH) | 2013-06-18 | — | — | US | disclosed |
| US-20110190334-A1 | Heterocyclic Sulfonamide Derivatives | NOVARTIS AG (CH) | 2011-08-04 | — | — | US | disclosed |
| US-20110190334-A1 | Heterocyclic Sulfonamide Derivatives | NOVARTIS AG (CH) | 2011-08-04 | — | — | US | disclosed |
| WO-2011054828-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES USEFUL AS MEK INHIBITORS | NOVARTIS AG (CH) | 2011-05-12 | — | — | WO | disclosed |
| WO-2011054828-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES USEFUL AS MEK INHIBITORS | NOVARTIS AG (CH) | 2011-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190334-A1 | Heterocyclic Sulfonamide Derivatives | BRAF, KSR2, NRAS | MAP2K1 269/4885MAP2K2 184/4885TRPV1 1506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.