Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 17/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 17/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 17/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 17/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 17/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 17/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 17/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 17/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 17/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 17/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18733899 | 1.00 | HDAC3 (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18700765 | 0.81 | HDAC3 (0.35) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL20518392 | 0.81 | HDAC3 (0.35) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18733653 | 0.81 | HDAC3 (0.35) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL20518391 | 0.79 | HDAC3 (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL20518390 | 0.79 | HDAC3 (0.51) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18707266 | 0.78 | HDAC3 (0.39) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18733935 | 0.78 | HDAC3 (0.39) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14262387 | 0.72 | HTT (0.43) | HTTATM | |
| SCHEMBL18734284 | 0.70 | HDAC1 (0.46) | HDAC1HDAC2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017060854-A1 | BIARYL PYRAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-04-13 | — | — | WO | disclosed |