Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.69 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.63 |
| ▸ | APP | P05067 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17119077 | 0.89 | BACE1 (0.73) | BACE1BACE2 | |
| SCHEMBL17119218 | 0.89 | BACE1 (0.73) | BACE1BACE2 | |
| SCHEMBL18707427 | 0.89 | BACE1 (0.73) | BACE1BACE2 | |
| SCHEMBL18708105 | 0.88 | BACE1 (0.81) | BACE1BACE2 | |
| SCHEMBL16918337 | 0.84 | BACE1 (0.77) | BACE1BACE2 | |
| SCHEMBL18707432 | 0.83 | BACE1 (0.79) | BACE1BACE2 | |
| SCHEMBL15345220 | 0.82 | BACE1 (0.83) | BACE1BACE2 | |
| SCHEMBL17119321 | 0.82 | BACE1 (0.68) | BACE1 | |
| SCHEMBL16041472 | 0.82 | BACE1 (1.00) | BACE1 | |
| SCHEMBL16042353 | 0.82 | BACE1 (1.00) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611261-B2 | Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use | AMGEN INC. (US) | 2017-04-04 | — | — | US | disclosed |