Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 14/20 | 0.57 |
| ▸ | KDM5C | P41229 | 8/20 | 0.57 |
| ▸ | KDM5A | P29375 | 7/20 | 0.57 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.57 |
| ▸ | KDM4A | O75164 | 2/20 | 0.53 |
| ▸ | KDM6B | O15054 | 1/20 | 0.53 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.53 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15636841 | 0.95 | KDM5B (0.59) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL16291503 | 0.88 | KDM5B (0.61) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL18708535 | 0.87 | KDM5B (0.47) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL19549155 | 0.86 | KDM5B (0.57) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL18708530 | 0.85 | KDM5B (0.59) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL16309158 | 0.84 | KDM5B (0.45) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15636185 | 0.83 | KDM5B (0.66) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL16292296 | 0.82 | KDM5B (0.42) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL28438423 | 0.80 | KDM5B (0.59) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL17763285 | 0.80 | KDM5B (0.63) | KDM5BKDM5CKDM5AKDM4CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3150582-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-04-05 | — | — | EP | disclosed |