Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.54 |
| ▸ | RARA | P10276 | 1/20 | 0.52 |
| ▸ | RARB | P10826 | 1/20 | 0.52 |
| ▸ | RARG | P13631 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 13/20 | 0.51 |
| ▸ | RAB9A | P51151 | 13/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.51 |
| ▸ | TSHR | P16473 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18708449 | 0.90 | MYC (0.54) | MYCRARARARBRARGNPC1 | |
| SCHEMBL12171448 | 0.88 | NPC1 (0.68) | MYCRARARARBRARGNPC1 | |
| SCHEMBL12170929 | 0.88 | MYC (0.56) | MYCRARARARBRARGNPC1 | |
| SCHEMBL18708465 | 0.86 | NPC1 (0.59) | MYCRARARARBRARGNPC1 | |
| SCHEMBL12171415 | 0.85 | NPC1 (0.52) | MYCRARARARBRARGNPC1 | |
| SCHEMBL12171750 | 0.85 | MYC (0.56) | MYCRARARARBRARGNPC1 | |
| SCHEMBL4414554 | 0.85 | NPC1 (0.57) | MYCNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL12171898 | 0.84 | NPC1 (0.69) | MYCNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL12172030 | 0.84 | MYC (0.55) | MYCRARARARBRARGNPC1 | |
| SCHEMBL12171918 | 0.84 | CA1 (0.52) | MYCRARARARBRARGNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611230-B2 | 1,3,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease | PTC THERAPEUTICS, INC. (US) | 2017-04-04 | — | — | US | disclosed |