Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.64 |
| ▸ | EGFR | P00533 | 9/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.64 |
| ▸ | LCK | P06239 | 5/20 | 0.64 |
| ▸ | KDR | P35968 | 5/20 | 0.64 |
| ▸ | MAP4K5 | Q9Y4K4 | 5/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.64 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.64 |
| ▸ | STK3 | Q13188 | 4/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.64 |
| ▸ | SYK | P43405 | 3/20 | 0.64 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.64 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.64 |
| ▸ | CSF1R | P07333 | 3/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.64 |
| ▸ | FYN | P06241 | 3/20 | 0.64 |
| ▸ | RET | P07949 | 3/20 | 0.64 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1789167 | 0.93 | IGF1R (0.71) | IGF1REGFRERBB2LCKKDR | |
| SCHEMBL1788634 | 0.91 | IGF1R (0.62) | IGF1REGFRERBB2LCKKDR | |
| SCHEMBL1789150 | 0.89 | IGF1R (0.67) | IGF1REGFRERBB2LCKKDR | |
| SCHEMBL1791235 | 0.89 | IGF1R (0.79) | IGF1REGFRERBB2LCKKDR | |
| SCHEMBL1790887 | 0.89 | IGF1R (0.61) | IGF1REGFRERBB2LCKKDR | |
| SCHEMBL1787369 | 0.89 | IGF1R (0.80) | IGF1REGFRERBB2LCKKDR | |
| SCHEMBL1791539 | 0.89 | BRAF (0.70) | IGF1REGFRERBB2LCKKDR | |
| SCHEMBL1788491 | 0.88 | IGF1R (0.61) | IGF1REGFRERBB2LCKKDR | |
| SCHEMBL1788930 | 0.88 | PTK2 (0.62) | IGF1REGFRERBB2LCKKDR | |
| SCHEMBL1791811 | 0.88 | IGF1R (0.66) | IGF1REGFRERBB2LCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496574-A1 | IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION | Abbott Laboratories (US) | 2012-09-12 | — | — | EP | claimed |
| WO-2011053476-A1 | IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION | ABBOTT LABORATORIES (US) | 2011-05-05 | — | — | WO | claimed |