Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14241975 | 0.87 | GAA (0.65) | SMN1; SMN2GAAALDH1A1KDM4ECYP2C9 | |
| SCHEMBL23480154 | 0.87 | GAA (0.65) | SMN1; SMN2GAAALDH1A1KDM4ECYP2C9 | |
| SCHEMBL9558762 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2GAAALDH1A1KDM4EACACB | |
| SCHEMBL9558751 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2GAAALDH1A1KDM4EACACB | |
| SCHEMBL10308293 | 0.81 | GAA (0.61) | SMN1; SMN2GAAALDH1A1KDM4ECYP2C9 | |
| SCHEMBL24567736 | 0.81 | GAA (0.61) | SMN1; SMN2GAAALDH1A1KDM4ECYP2C9 | |
| SCHEMBL18714403 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2GAAALDH1A1ACACBL3MBTL1 | |
| SCHEMBL12448285 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2GAAHTTLMNA | |
| SCHEMBL3634427 | 0.80 | SMN1; SMN2 (0.46) | SMN1; SMN2GAAACACBL3MBTL1HTT | |
| SCHEMBL15199110 | 0.80 | GAA (0.58) | SMN1; SMN2GAAALDH1A1KDM4ECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9610284-B2 | 4-(8-methoxy-1-((1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole and its use as bromodomain inhibitor | GLAXOSMITHKLINE LLC (US) | 2017-04-04 | — | — | US | disclosed |