Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 8/20 | 0.47 |
| ▸ | LPAR3 | Q9UBY5 | 4/20 | 0.38 |
| ▸ | TLR2 | O60603 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | NMT2 | O60551 | 1/20 | 0.32 |
| ▸ | NMT1 | P30419 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18715477 | 1.00 | GLP1R (0.47) | GLP1RLPAR3TLR2MEN1KMT2A | |
| SCHEMBL20017564 | 0.92 | GLP1R (0.46) | GLP1RLPAR3TLR2MEN1KMT2A | |
| SCHEMBL18715473 | 0.90 | GLP1R (0.46) | GLP1RLPAR3TLR2MEN1KMT2A | |
| SCHEMBL18708284 | 0.89 | GLP1R (0.46) | GLP1RLPAR3TLR2MEN1KMT2A | |
| SCHEMBL26524137 | 0.86 | GLP1R (0.45) | GLP1RLPAR3TLR2MEN1KMT2A | |
| SCHEMBL22172474 | 0.85 | GLP1R (0.41) | GLP1RLPAR3TLR2MEN1KMT2A | |
| SCHEMBL19320390 | 0.84 | GLP1R (0.58) | GLP1RLPAR3TLR2LPAR1 | |
| SCHEMBL20375605 | 0.84 | GLP1R (0.47) | GLP1RLPAR3TLR2MEN1KMT2A | |
| SCHEMBL26524141 | 0.83 | GLP1R (0.44) | GLP1RLPAR3TLR2MEN1KMT2A | |
| SCHEMBL20375472 | 0.83 | GLP1R (0.46) | GLP1RLPAR3TLR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170096665-A1 | Compositions and Methods for Inhibiting Gene Expression of LPA | Arrowhead Pharmaceuticals, Inc. | 2017-04-06 | — | — | US | disclosed |