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SCHEMBL18716899

SCHEMBL18716899

CNC(=N)NCCCC(NC=O)C(=O)N[C@@H](C)C(=O)NC(CCCNC(=O)CCC(NC(=O)CNC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NC(C)Cc1ccccc1)C(=O)O

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ NPY5R Q15761 4/20 0.44
▸ NPY4R P50391 4/20 0.44
▸ NPY1R P25929 3/20 0.44
▸ TFPI P10646 1/20 0.40
▸ KISS1R Q969F8 1/20 0.40
▸ IL23R Q5VWK5 1/20 0.40
▸ NPY2R P49146 1/20 0.39
▸ NPBWR1 P48145 1/20 0.39
▸ OPRL1 P41146 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21392371 0.86 TFPI (0.44) NPY5RNPY4RNPY1RTFPIIL23R
SCHEMBL24488464 0.82 NPY4R (0.49) NPY5RNPY4RNPY1RKISS1RNPY2R
SCHEMBL18717030 0.78 TFPI (0.52) NPY5RNPY4RNPY1RTFPIKISS1R
SCHEMBL18717071 0.78 TFPI (0.44) NPY5RNPY4RNPY1RTFPIKISS1R
SCHEMBL24488479 0.78 NPY4R (0.51) NPY5RNPY4RNPY1RKISS1RNPY2R
SCHEMBL18716871 0.77 MC4R (0.50) KISS1RIL23RNPBWR1
SCHEMBL19473910 0.75 PTPN2 (0.42) TFPIKISS1RIL23R
SCHEMBL24158319 0.75 TFPI (0.48) NPY5RNPY4RNPY1RTFPIIL23R
SCHEMBL19473938 0.74 GNPAT (0.47) NPY5RNPY4RNPY1RTFPIKISS1R
SCHEMBL21173489 0.74 IL23R (0.54) KISS1RIL23R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2440572-B1 LACTAM-BRIDGED MELANOCORTIN RECEPTOR-SPECIFIC PEPTIDES PALATIN TECHNOLOGIES INC (US) 2017-04-05 — — EP disclosed
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