Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 18/20 | 0.74 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.72 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.72 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.72 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1869537 | 0.96 | BCL2 (0.76) | BCL2BCL2L1MCL1TMEM97BCL2L2 | |
| SCHEMBL1700179 | 0.91 | BCL2 (0.89) | BCL2BCL2L1MCL1TMEM97BCL2L2 | |
| SCHEMBL29657405 | 0.91 | BCL2 (0.89) | BCL2BCL2L1MCL1TMEM97BCL2L2 | |
| SCHEMBL1701495 | 0.91 | BCL2 (0.89) | BCL2BCL2L1MCL1TMEM97BCL2L2 | |
| SCHEMBL1700182 | 0.91 | BCL2 (0.89) | BCL2BCL2L1MCL1TMEM97BCL2L2 | |
| SCHEMBL1955823 | 0.88 | BCL2 (0.71) | BCL2 | |
| SCHEMBL19292332 | 0.87 | BCL2 (0.83) | BCL2BCL2L1MCL1TMEM97BCL2L2 | |
| SCHEMBL16908909 | 0.87 | BCL2 (0.79) | BCL2BCL2L1MCL1TMEM97BCL2L2 | |
| SCHEMBL1700720 | 0.86 | BCL2 (0.92) | BCL2BCL2L1MCL1TMEM97BCL2L2 | |
| SCHEMBL1700715 | 0.86 | BCL2 (0.92) | BCL2BCL2L1MCL1TMEM97BCL2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435432-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2012-04-04 | — | — | EP | disclosed |
| WO-2010138588-A9 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-05-05 | — | — | WO | disclosed |
| WO-2010138588-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |