Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 15/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.52 |
| ▸ | GSK3B | P49841 | 7/20 | 0.52 |
| ▸ | GRK6 | P43250 | 7/20 | 0.47 |
| ▸ | SRC | P12931 | 4/20 | 0.46 |
| ▸ | IGF1R | P08069 | 4/20 | 0.44 |
| ▸ | GRK4 | P32298 | 3/20 | 0.44 |
| ▸ | GRK5 | P34947 | 3/20 | 0.44 |
| ▸ | GRK1 | Q15835 | 3/20 | 0.44 |
| ▸ | GRK7 | Q8WTQ7 | 3/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174435 | 0.84 | AURKA (0.50) | AURKAAURKBGSK3BGRK6SRC | |
| Hydrochloric Acid SCHEMBL174764 | 0.83 | AURKA (0.49) | AURKAAURKBGSK3BGRK6SRC | |
| SCHEMBL174782 | 0.80 | NTRK1 (0.47) | AURKAAURKBGSK3BGRK6SRC | |
| SCHEMBL15232334 | 0.78 | AURKA (0.76) | AURKAAURKBGSK3BSRCNTRK1 | |
| Hydrochloric Acid SCHEMBL28561065 | 0.77 | AURKA (0.74) | AURKAAURKBGSK3BSRCNTRK1 | |
| SCHEMBL802034 | 0.73 | AURKA (0.69) | AURKAAURKBGSK3BSRCNTRK1 | |
| SCHEMBL174948 | 0.72 | SYK (0.42) | AURKAAURKBGSK3BSRCNTRK1 | |
| SCHEMBL14432758 | 0.71 | NTRK1 (0.47) | AURKAAURKBGSK3BSRCNTRK1 | |
| SCHEMBL12430500 | 0.69 | AURKA (1.00) | AURKAAURKBGSK3BSRCEIF2AK2 | |
| SCHEMBL17501774 | 0.68 | AURKA (0.53) | AURKAAURKBGSK3BSRCNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401267-A1 | JAK KINASE MODULATING QUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010099379-A1 | JAK KINASE MODULATING QUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2010-09-02 | — | — | WO | disclosed |