Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 17/20 | 0.52 |
| ▸ | ACE | P12821 | 8/20 | 0.52 |
| ▸ | MMEL1 | Q495T6 | 4/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19190740 | 1.00 | MME (0.52) | MMEACEMMEL1TAAR1 | |
| SCHEMBL17011198 | 1.00 | MME (0.52) | MMEACEMMEL1TAAR1 | |
| SCHEMBL17011205 | 0.89 | MME (0.50) | MMEACEMMEL1TAAR1 | |
| SCHEMBL19190725 | 0.89 | MME (0.50) | MMEACEMMEL1TAAR1 | |
| SCHEMBL18724846 | 0.89 | MME (0.50) | MMEACEMMEL1TAAR1 | |
| SCHEMBL14890860 | 0.89 | MME (0.50) | MMEACEMMEL1TAAR1 | |
| SCHEMBL18597751 | 0.89 | MME (0.50) | MMEACEMMEL1TAAR1 | |
| SCHEMBL16024098 | 0.88 | MME (0.55) | MMEACEMMEL1TAAR1 | |
| SCHEMBL14918910 | 0.88 | MME (0.55) | MMEACEMMEL1TAAR1 | |
| SCHEMBL14919277 | 0.88 | MME (0.55) | MMEACEMMEL1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864292-B1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2017-04-12 | — | — | EP | disclosed |