Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 18/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LSS | P48449 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1869542 | 0.96 | AVPR1B (0.53) | AVPR1BCYP3A4GAAL3MBTL1 | |
| SCHEMBL1877194 | 0.94 | AVPR1B (0.52) | AVPR1BCYP3A4 | |
| SCHEMBL1871972 | 0.93 | AVPR1B (0.58) | AVPR1BCYP3A4 | |
| SCHEMBL1877236 | 0.91 | AVPR1B (0.52) | AVPR1BCYP3A4 | |
| SCHEMBL1877534 | 0.91 | AVPR1B (0.51) | AVPR1BCYP3A4 | |
| SCHEMBL1873861 | 0.91 | AVPR1B (0.51) | AVPR1BCYP3A4 | |
| SCHEMBL1872974 | 0.91 | AVPR1B (0.51) | AVPR1BCYP3A4 | |
| SCHEMBL1873449 | 0.91 | AVPR1B (0.51) | AVPR1BCYP3A4 | |
| SCHEMBL1871365 | 0.90 | AVPR1B (0.57) | AVPR1BCYP3A4 | |
| SCHEMBL1874938 | 0.88 | AVPR1B (0.50) | AVPR1BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227463-B1 | SUBSTITUTED OXINDOLE-DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT ILLNESSES | ABBVIE DEUTSCHLAND (DE) | 2016-08-17 | — | — | EP | claimed |
| US-9238642-B2 | Substituted oxindole-derivatives and the use thereof for the treatment of vasopressin-dependent illnesses | AbbVie Deutschland GmbH & Co. KG (DE) | 2016-01-19 | — | — | US | claimed |
| US-8629148-B2 | Substituted oxindole-derivatives and the use thereof for the treatment of vasopressin-dependent illnesses | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-01-14 | — | — | US | claimed |
| EP-2227463-B1 | SUBSTITUTED OXINDOLE-DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT ILLNESSES | ABBVIE DEUTSCHLAND (DE) | 2016-08-17 | — | — | EP | disclosed |
| US-9238642-B2 | Substituted oxindole-derivatives and the use thereof for the treatment of vasopressin-dependent illnesses | AbbVie Deutschland GmbH & Co. KG (DE) | 2016-01-19 | — | — | US | disclosed |
| US-20140303138-A1 | SUBSTITUTED OXINDOLE-DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT ILLNESSES | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-10-09 | — | — | US | disclosed |
| US-8629148-B2 | Substituted oxindole-derivatives and the use thereof for the treatment of vasopressin-dependent illnesses | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-01-14 | — | — | US | disclosed |
| US-20110105454-A1 | SUBSTITUTED OXINDOLE-DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT ILLNESSES | ABBOTT GMBH & CO. KG (DE) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303138-A1 | SUBSTITUTED OXINDOLE-DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT ILLNESSES | AVPR2, AVPR1B, AVPR1A | AVPR1B 2/4885CYP3A4 1566/4885GAA 3576/4885 |
| US-20110105454-A1 | SUBSTITUTED OXINDOLE-DERIVATIVES AND THE USE THEREOF FOR THE TREATMENT OF VASOPRESSIN-DEPENDENT ILLNESSES | AVPR2, AVPR1B, AVPR1A | AVPR1B 2/4885CYP3A4 1566/4885GAA 3576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.