Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.56 |
| ▸ | JAK2 | O60674 | 19/20 | 0.56 |
| ▸ | JAK3 | P52333 | 19/20 | 0.56 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18720814 | 0.88 | JAK1 (0.62) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL18732879 | 0.87 | JAK1 (0.61) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL18720790 | 0.87 | JAK1 (0.61) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2460184 | 0.82 | JAK1 (0.61) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL12299936 | 0.80 | JAK1 (0.66) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL18720803 | 0.80 | JAK1 (0.57) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL18720812 | 0.80 | JAK1 (0.57) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL18720820 | 0.79 | JAK1 (0.56) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL18733253 | 0.78 | JAK1 (0.55) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL18732884 | 0.78 | JAK1 (0.54) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017060470-A1 | PYRROLOPYRAZINE DERIVATIVES FOR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA | F. HOFFMANN-LA ROCHE AG (CH) | 2017-04-13 | — | — | WO | disclosed |