Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18322375 | 0.86 | KCNA5 (0.48) | KCNA5KDM4ANAMPTHDAC10HDAC6 | |
| SCHEMBL30236239 | 0.86 | KCNA5 (0.48) | KCNA5KDM4ANAMPTHDAC10HDAC6 | |
| SCHEMBL8018113 | 0.85 | KCNA5 (0.56) | KCNA5KDM4ANAMPTHDAC10HDAC6 | |
| SCHEMBL30159605 | 0.85 | KCNA5 (0.56) | KCNA5KDM4ANAMPTHDAC10HDAC6 | |
| SCHEMBL18322695 | 0.85 | KCNA5 (0.43) | KCNA5KDM4ANAMPTHDAC10HDAC6 | |
| SCHEMBL18706904 | 0.83 | KCNA5 (0.50) | KCNA5KDM4ANAMPTHDAC10HDAC6 | |
| SCHEMBL6874894 | 0.80 | KCNA5 (0.52) | KCNA5KDM4ANAMPTHDAC10HDAC6 | |
| SCHEMBL30454240 | 0.80 | KCNA5 (0.52) | KCNA5KDM4ANAMPTHDAC10HDAC6 | |
| SCHEMBL5841647 | 0.79 | KCNA5 (0.52) | KCNA5KDM4ANAMPTHDAC10HDAC6 | |
| SCHEMBL6924987 | 0.79 | KCNA5 (0.51) | KCNA5KDM4ANAMPTHDAC10HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3782996-A1 | NRF2 REGULATORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2021-02-24 | — | — | EP | disclosed |
| EP-3307739-B1 | NRF2 REGULATORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-10-07 | — | — | EP | disclosed |
| WO-2017060854-A1 | BIARYL PYRAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-04-13 | — | — | WO | disclosed |