Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Idarubicin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A known ✓ | P11388 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 9/20 | 1.00 |
| ▸ | THRB | P10828 | 9/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 9/20 | 1.00 |
| ▸ | BLM | P54132 | 8/20 | 1.00 |
| ▸ | RECQL | P46063 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | BRCA1 | P38398 | 6/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 6/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 5/20 | 1.00 |
| ▸ | HTT | P42858 | 5/20 | 1.00 |
| ▸ | S100A4 | P26447 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | USP2 | O75604 | 4/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 4/20 | 1.00 |
| ▸ | STAT6 | P42226 | 4/20 | 1.00 |
| ▸ | APEX1 | P27695 | 3/20 | 1.00 |
| ▸ | NPC1 | O15118 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Idarubicin SCHEMBL13488561 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Idarubicin SCHEMBL16609956 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Idarubicin SCHEMBL12257447 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Idarubicin SCHEMBL15159345 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Idarubicin SCHEMBL13575798 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Idarubicin SCHEMBL3750 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Idarubicin SCHEMBL16606206 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Idarubicin SCHEMBL7029978 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Idarubicin SCHEMBL20541733 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL | |
| Idarubicin SCHEMBL10061859 | 1.00 | MEN1 (1.00) | MEN1THRBKMT2ABLMRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017062800-A1 | TRIGGER-ACTIVATABLE METABOLIC SUGAR PRECURSORS FOR CANCER-SELECTIVE LABELING AND TARGETING | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-04-13 | — | — | WO | disclosed |