Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 19/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.59 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | PRKDC | P78527 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1869519 | 0.90 | PIK3CB (0.73) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL1869138 | 0.90 | PIK3CB (0.56) | PIK3CBPIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL1865332 | 0.84 | PIK3CB (0.53) | PIK3CBPIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL1872855 | 0.84 | PIK3CB (0.74) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL24713938 | 0.81 | PIK3CA (0.53) | PIK3CBPIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL1638560 | 0.81 | PIK3CB (0.61) | PIK3CBPIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL1638566 | 0.81 | PIK3CB (0.61) | PIK3CBPIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL29826867 | 0.81 | PIK3CA (0.53) | PIK3CBPIK3CAPIK3CDPIK3CGMTOR | |
| SCHEMBL1866749 | 0.81 | PIK3CB (0.72) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| Bromide SCHEMBL1865317 | 0.81 | PIK3CB (0.71) | PIK3CBPIK3CAPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493870-A1 | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | AstraZeneca AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011051704-A1 | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2011-05-05 | — | — | WO | disclosed |