Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30181410 | 0.81 | NR1H2 (0.41) | NR1H2CTSKHSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL1178045 | 0.79 | NR1H2 (0.41) | NR1H2CTSKHSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL1178043 | 0.79 | NR1H2 (0.41) | NR1H2CTSKHSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL1178044 | 0.79 | NR1H2 (0.41) | NR1H2CTSKHSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL12870257 | 0.79 | NR1H2 (0.41) | NR1H2CTSKHSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL16914071 | 0.77 | NR1H2 (0.40) | NR1H2CTSKHSD17B10SMN1; SMN2RXRA | |
| SCHEMBL23545833 | 0.76 | HSD17B10 (0.39) | NR1H2ALDH1A1CTSKHSD17B10SMN1; SMN2 | |
| SCHEMBL29805015 | 0.76 | HSD17B10 (0.39) | NR1H2ALDH1A1CTSKHSD17B10SMN1; SMN2 | |
| SCHEMBL17922894 | 0.76 | HSD17B10 (0.42) | ALDH1A1CTSKHSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL17922929 | 0.76 | HSD17B10 (0.42) | ALDH1A1CTSKHSD17B10SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3362443-A1 | COMPOUNDS USEFUL AS IMMUNOMODULATORS | Bristol-Myers Squibb Company (US) | 2018-08-22 | — | — | EP | disclosed |
| WO-2017066227-A1 | COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-04-20 | — | — | WO | disclosed |