Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 19/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18732868 | 0.92 | CFTR (0.60) | CFTRCYP2C9HRH1TMEM97SIGMAR1 | |
| SCHEMBL18694176 | 0.85 | CFTR (0.72) | CFTRCYP2C9HRH1TMEM97SIGMAR1 | |
| SCHEMBL18694002 | 0.85 | CFTR (0.61) | CFTRCYP2C9HRH1TMEM97SIGMAR1 | |
| SCHEMBL18693302 | 0.85 | CFTR (0.64) | CFTRCYP2C9HRH1TMEM97SIGMAR1 | |
| SCHEMBL18694085 | 0.85 | CFTR (0.65) | CFTRCYP2C9HRH1TMEM97SIGMAR1 | |
| SCHEMBL18693595 | 0.85 | CFTR (0.65) | CFTRCYP2C9HRH1TMEM97SIGMAR1 | |
| SCHEMBL18693073 | 0.85 | CFTR (0.75) | CFTRCYP2C9HRH1TMEM97SIGMAR1 | |
| SCHEMBL18694703 | 0.85 | CFTR (0.75) | CFTRCYP2C9HRH1TMEM97SIGMAR1 | |
| SCHEMBL18693945 | 0.84 | CFTR (0.61) | CFTRCYP2C9HRH1TMEM97SIGMAR1 | |
| SCHEMBL18692318 | 0.84 | CFTR (0.62) | CFTRCYP2C9HRH1TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017060873-A1 | SUBSTITUTED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXYLIC ACIDS AND THEIR USE | AbbVie S.à.r.l. (LU) | 2017-04-13 | — | — | WO | disclosed |