Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 14/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18732473 | 0.88 | CFTR (0.63) | CFTRMAPTMEN1KMT2AKDM4E | |
| SCHEMBL18692799 | 0.88 | CFTR (0.63) | CFTRMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL18692053 | 0.86 | CFTR (0.65) | CFTRMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL18694527 | 0.86 | CFTR (0.56) | CFTRMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL18694088 | 0.85 | CFTR (0.68) | CFTR | |
| SCHEMBL18739927 | 0.85 | CFTR (0.68) | CFTRMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL18717664 | 0.84 | CFTR (0.59) | CFTRKDM4EHSD17B10HPGD | |
| SCHEMBL18732764 | 0.83 | CFTR (0.80) | CFTR | |
| SCHEMBL18694702 | 0.83 | CFTR (0.61) | CFTR | |
| SCHEMBL18732252 | 0.83 | CFTR (0.71) | CFTRMEN1KMT2AKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017060873-A1 | SUBSTITUTED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXYLIC ACIDS AND THEIR USE | AbbVie S.à.r.l. (LU) | 2017-04-13 | — | — | WO | disclosed |