Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 6/20 | 0.32 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4276978 | 0.68 | PAK1 (0.43) | PAK1JAK1JAK2JAK3TYK2 | |
| SCHEMBL4279363 | 0.68 | PAK1 (0.43) | PAK1JAK1JAK2JAK3TYK2 | |
| SCHEMBL4279881 | 0.68 | PAK1 (0.48) | PAK1JAK1JAK2JAK3TYK2 | |
| SCHEMBL4277415 | 0.68 | PAK1 (0.48) | PAK1JAK1JAK2JAK3TYK2 | |
| SCHEMBL4282165 | 0.68 | PAK1 (0.43) | PAK1JAK1JAK2JAK3 | |
| SCHEMBL4286098 | 0.68 | PAK1 (0.43) | PAK1JAK1JAK2JAK3 | |
| SCHEMBL4281658 | 0.67 | PAK1 (0.42) | PAK1BRAFJAK1JAK2JAK3 | |
| SCHEMBL4283127 | 0.67 | PAK1 (0.42) | PAK1BRAFJAK1JAK2JAK3 | |
| SCHEMBL4277920 | 0.66 | CHRNA7 (0.34) | PAK1BRAFJAK1 | |
| SCHEMBL13657917 | 0.66 | CHRNA7 (0.34) | PAK1BRAFJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624229-B2 | Pyrimidine-2-amine compounds and their use as inhibitors of JAK kinases | RIGEL PHARMACEUTICALS, INC. (US) | 2017-04-18 | — | — | US | disclosed |