Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 6/20 | 0.35 |
| ▸ | AR | P10275 | 3/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1872504 | 0.92 | BRAF (0.42) | RIPK2BRAFKCNH2EGFRAR | |
| SCHEMBL1874929 | 0.91 | PTPN11 (0.37) | EGFR | |
| SCHEMBL1871408 | 0.90 | RIPK2 (0.37) | RIPK2BRAFKCNH2EGFRAR | |
| SCHEMBL1870361 | 0.89 | RIPK2 (0.40) | RIPK2BRAFKCNH2EGFRGAA | |
| SCHEMBL1866903 | 0.88 | RIPK2 (0.40) | RIPK2BRAFKCNH2EGFR | |
| SCHEMBL1875785 | 0.87 | BRAF (0.40) | RIPK2BRAFKCNH2EGFR | |
| SCHEMBL1872280 | 0.85 | EGFR (0.38) | BRAFEGFR | |
| SCHEMBL1870842 | 0.83 | EGFR (0.37) | RIPK2BRAFEGFR | |
| SCHEMBL1873056 | 0.83 | BRAF (0.32) | BRAF | |
| SCHEMBL1875729 | 0.83 | BRAF (0.42) | RIPK2BRAFKCNH2EGFRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |