Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.64 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4438262 | 0.99 | HRH3 (0.63) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL3712281 | 0.88 | HRH3 (0.62) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL1873259 | 0.87 | HRH3 (0.64) | HRH3HRH1 | |
| SCHEMBL6261967 | 0.80 | HRH3 (0.51) | HRH3HRH1 | |
| [11C]Gsk-189254 SCHEMBL13217225 | 0.78 | HRH3 (1.00) | HRH3HRH1 | |
| Gsk189254 SCHEMBL13788699 | 0.78 | HRH3 (1.00) | HRH3HRH1 | |
| Gsk189254 SCHEMBL29769888 | 0.78 | HRH3 (1.00) | HRH3HRH1 | |
| Gsk189254 SCHEMBL169579 | 0.78 | HRH3 (1.00) | HRH3HRH1 | |
| SCHEMBL3077653 | 0.78 | HRH3 (0.67) | HRH3HRH1OPRM1OPRD1OPRK1 | |
| SCHEMBL3333687 | 0.78 | PDE4B (0.48) | HRH3HRH1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2131846-A1 | NOVEL DOSAGE FORM | Glaxo Group Limited (GB) | 2009-12-16 | — | — | EP | claimed |
| WO-2008104589-A1 | NOVEL DOSAGE FORM | GLAXO GROUP LIMITED (GB) | 2008-09-04 | — | — | WO | claimed |
| WO-2011051423-A1 | TREATMENT OR PROPHYLAXIS OF DEMENTIA, NEURODEGENERATIVE DISORDERS, SCHIZOPHRENIA, ADHD, SOMNOLENCE OR EPILEPSY | GLAXO GROUP LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |
| EP-2131846-A1 | NOVEL DOSAGE FORM | Glaxo Group Limited (GB) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008104589-A1 | NOVEL DOSAGE FORM | GLAXO GROUP LIMITED (GB) | 2008-09-04 | — | — | WO | disclosed |