Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 20/20 | 0.60 |
| ▸ | CDK2 | P24941 | 20/20 | 0.60 |
| ▸ | CCNA1 | P78396 | 18/20 | 0.60 |
| ▸ | AURKA | O14965 | 11/20 | 0.60 |
| ▸ | PLK1 | P53350 | 9/20 | 0.59 |
| ▸ | PLK3 | Q9H4B4 | 5/20 | 0.59 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.59 |
| ▸ | CDK4 | P11802 | 3/20 | 0.59 |
| ▸ | CCND3 | P30281 | 3/20 | 0.59 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.59 |
| ▸ | TTK | P33981 | 2/20 | 0.59 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3503440 | 0.82 | CCNA2 (0.65) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL16572387 | 0.82 | CCNA2 (0.66) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL3503045 | 0.81 | CCNA2 (0.64) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL13852050 | 0.79 | CCNA2 (0.74) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL4147700 | 0.79 | CCNA2 (0.64) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL9940632 | 0.78 | CCNA2 (0.61) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL4159100 | 0.78 | CCNA2 (0.63) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL9940730 | 0.77 | CCNA2 (0.62) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL11024245 | 0.76 | CCNA2 (0.60) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL9940739 | 0.76 | CCNA2 (0.64) | CCNA2CDK2CCNA1AURKAPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614065-B1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2017-04-19 | — | — | EP | disclosed |