Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.62 |
| ▸ | S1PR3 | Q99500 | 12/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.53 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.53 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2140132 | 0.82 | S1PR1 (0.63) | S1PR1S1PR3KCNH2S1PR5S1PR2 | |
| SCHEMBL2131514 | 0.81 | S1PR1 (0.65) | S1PR1S1PR3KCNH2S1PR5S1PR2 | |
| SCHEMBL12434090 | 0.81 | S1PR1 (0.58) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1878046 | 0.81 | S1PR1 (0.65) | S1PR1S1PR3KCNH2S1PR5S1PR2 | |
| SCHEMBL2134973 | 0.80 | S1PR1 (0.63) | S1PR1S1PR3KCNH2S1PR5S1PR2 | |
| SCHEMBL1398509 | 0.80 | S1PR1 (0.63) | S1PR1S1PR3KCNH2S1PR5S1PR2 | |
| SCHEMBL1878972 | 0.79 | S1PR1 (0.62) | S1PR1S1PR3KCNH2S1PR5 | |
| SCHEMBL1965041 | 0.79 | S1PR1 (0.62) | S1PR1S1PR3KCNH2S1PR5S1PR2 | |
| SCHEMBL1965122 | 0.79 | S1PR1 (0.62) | S1PR1S1PR3KCNH2S1PR5S1PR2 | |
| SCHEMBL28656867 | 0.79 | S1PR1 (0.62) | S1PR1S1PR3KCNH2S1PR5S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498611-B1 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | CELGENE INT II SÀRL (CH) | 2018-01-10 | — | — | EP | disclosed |
| US-9394264-B2 | Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis | RECEPTOS, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394264-B2 | Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis | RECEPTOS, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-20150299150-A1 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS LLC | 2015-10-22 | — | — | US | disclosed |
| US-20150299150-A1 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS LLC | 2015-10-22 | — | — | US | disclosed |
| US-20130196966-A1 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS, INC. (US) | 2013-08-01 | — | — | US | disclosed |
| US-20130196966-A1 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS, INC. (US) | 2013-08-01 | — | — | US | disclosed |
| US-20130196966-A1 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS, INC. (US) | 2013-08-01 | — | — | US | disclosed |
| US-8357706-B2 | Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis | RECEPTOS, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-8357706-B2 | Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis | RECEPTOS, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| CN-102724880-A | Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis | RECEPTOS INC | 2012-10-10 | — | — | CN | disclosed |
| EP-2498611-A1 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | Receptos, Inc. (US) | 2012-09-19 | — | — | EP | disclosed |
| US-20110178056-A1 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS LLC | 2011-07-21 | — | — | US | disclosed |
| US-20110178056-A1 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS LLC | 2011-07-21 | — | — | US | disclosed |
| WO-2011060389-A1 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011060389-A1 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | RECEPTOS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130196966-A1 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | S1PR1, S1PR3, S1PR2 | S1PR1 1/4885S1PR3 2/4885KCNH2 1878/4885 |
| US-20150299150-A1 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | S1PR1, S1PR3, S1PR2 | S1PR1 1/4885S1PR3 2/4885KCNH2 1878/4885 |
| US-20110178056-A1 | SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS | S1PR1, S1PR3, S1PR2 | S1PR1 1/4885S1PR3 2/4885KCNH2 1882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.