Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 12/20 | 0.46 |
| ▸ | BRAF | P15056 | 11/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2792969 | 0.89 | KDR (0.53) | KDRRIPK1HTR2AHTR2CHTR2B | |
| SCHEMBL11966503 | 0.88 | KDR (0.66) | KDRRIPK1HTR2AHTR2CHTR2B | |
| SCHEMBL11966506 | 0.88 | KDR (0.57) | KDRRIPK1HTR2AHTR2CHTR2B | |
| SCHEMBL11966504 | 0.88 | KDR (0.68) | KDRRIPK1HTR2AHTR2CHTR2B | |
| SCHEMBL11966514 | 0.87 | KDR (0.54) | KDRRIPK1HTR2AHTR2CHTR2B | |
| SCHEMBL11966501 | 0.87 | KDR (0.52) | KDRRIPK1HTR2AHTR2CHTR2B | |
| SCHEMBL11966508 | 0.86 | KDR (0.54) | KDRRIPK1HTR2AHTR2CHTR2B | |
| SCHEMBL11966509 | 0.86 | KDR (0.54) | KDRRIPK1HTR2AHTR2CHTR2B | |
| SCHEMBL11966510 | 0.86 | KDR (0.53) | KDRRIPK1HTR2AHTR2CHTR2B | |
| SCHEMBL11966512 | 0.86 | KDR (0.57) | KDRRIPK1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376478-B1 | PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2017-04-19 | — | — | EP | disclosed |