Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 13/20 | 0.58 |
| ▸ | HRH1 | P35367 | 3/20 | 0.49 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1877811 | 0.93 | SSTR5 (0.66) | SSTR5HRH1SSTR1HTR2BALDH1A1 | |
| SCHEMBL1875202 | 0.89 | SSTR5 (0.55) | SSTR5HRH1SSTR1JAK1JAK3 | |
| SCHEMBL1872164 | 0.88 | SSTR5 (0.54) | SSTR5HRH1SSTR1JAK1JAK3 | |
| SCHEMBL1874927 | 0.87 | SSTR5 (0.54) | SSTR5HRH1SSTR1JAK1JAK3 | |
| SCHEMBL2421933 | 0.83 | SSTR5 (0.57) | SSTR5HRH1JAK1JAK3HTR2B | |
| SCHEMBL1870624 | 0.83 | SSTR5 (0.54) | SSTR5HRH1SSTR1HTR2BALDH1A1 | |
| SCHEMBL1876441 | 0.83 | SSTR5 (0.54) | SSTR5HRH1SSTR1HTR2BALDH1A1 | |
| SCHEMBL1873665 | 0.83 | SSTR5 (0.57) | SSTR5HRH1SSTR1HTR2BALDH1A1 | |
| SCHEMBL1878420 | 0.83 | SSTR5 (0.53) | SSTR5HRH1SSTR1ALDH1A1CCR5 | |
| SCHEMBL1875100 | 0.83 | SSTR5 (0.54) | SSTR5HRH1SSTR1HTR2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939661-B2 | Antidiabetic agents; somatostatin receptor subtype 5 modulators; noninsulin dependent diabetes mellitus; side effect reduction; synthesis | HOFFMAN-LA ROCHE INC. (US) | 2011-05-10 | — | — | US | claimed |
| US-20080064697-A1 | PYRIDINE, QUINOLINE AND PYRIMIDINE DERIVATIVES | HOFFMAN-LA ROCHE INC. | 2008-03-13 | — | — | US | claimed |
| US-7939661-B2 | Antidiabetic agents; somatostatin receptor subtype 5 modulators; noninsulin dependent diabetes mellitus; side effect reduction; synthesis | HOFFMAN-LA ROCHE INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-20080064697-A1 | PYRIDINE, QUINOLINE AND PYRIMIDINE DERIVATIVES | HOFFMAN-LA ROCHE INC. | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064697-A1 | PYRIDINE, QUINOLINE AND PYRIMIDINE DERIVATIVES | SSTR5, SSTR3, NPY5R | SSTR5 1/4885HRH1 97/4885SSTR1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.