Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 8/20 | 0.42 |
| ▸ | PDE2A | O00408 | 8/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28922411 | 1.00 | PTGER4 (0.42) | PTGER4PDE2APTGER2CYP1A2ALDH1A1 | |
| SCHEMBL18758538 | 0.95 | PDE2A (0.43) | PTGER4PDE2APTGER2CYP1A2ALDH1A1 | |
| SCHEMBL28961686 | 0.92 | BRD4 (0.45) | PTGER4CYP1A2ALDH1A1TSHRCYP2D6 | |
| SCHEMBL18758724 | 0.92 | BRD4 (0.45) | PTGER4CYP1A2ALDH1A1TSHRCYP2D6 | |
| SCHEMBL18758569 | 0.91 | PTGER4 (0.51) | PTGER4PTGER2 | |
| SCHEMBL20539536 | 0.91 | PTGER4 (0.51) | PTGER4PTGER2 | |
| SCHEMBL18758716 | 0.90 | PTGER4 (0.46) | PTGER4PTGER2 | |
| SCHEMBL28619681 | 0.90 | PTGER4 (0.46) | PTGER4PTGER2 | |
| SCHEMBL18758537 | 0.87 | PTGER4 (0.47) | PTGER4PTGER2CYP1A2CYP3A4TSHR | |
| SCHEMBL29894128 | 0.87 | PTGER4 (0.47) | PTGER4PTGER2CYP1A2CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11434246-B2 | EP4 antagonists | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2022-09-06 | — | — | US | disclosed |
| US-20210347779-A1 | EP4 ANTAGONISTS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2021-11-11 | — | — | US | disclosed |
| US-10316040-B2 | EP4 antagonists | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2019-06-11 | — | — | US | disclosed |
| WO-2017066633-A1 | EP4 ANTAGONISTS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11434246-B2 | EP4 antagonists | PTGER4, PTGER3, PTGER1 | PTGER4 1/4885PDE2A 265/4885PTGER2 4/4885 |
| US-10316040-B2 | EP4 antagonists | PTGER4, PTGER3, PTGER1 | PTGER4 1/4885PDE2A 265/4885PTGER2 4/4885 |
| US-20210347779-A1 | EP4 ANTAGONISTS | PTGER4, PTGER3, PTGER1 | PTGER4 1/4885PDE2A 265/4885PTGER2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.