Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.53 |
| ▸ | JAK1 | P23458 | 20/20 | 0.53 |
| ▸ | JAK3 | P52333 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18759704 | 1.00 | JAK2 (0.53) | JAK2JAK1JAK3 | |
| SCHEMBL22364286 | 0.86 | JAK2 (0.59) | JAK2JAK1JAK3 | |
| SCHEMBL22364289 | 0.82 | JAK2 (0.79) | JAK2JAK1JAK3 | |
| SCHEMBL12346404 | 0.81 | JAK2 (0.47) | JAK2JAK1JAK3 | |
| SCHEMBL2231021 | 0.81 | JAK2 (0.46) | JAK2JAK1JAK3 | |
| SCHEMBL2231024 | 0.81 | JAK2 (0.46) | JAK2JAK1JAK3 | |
| SCHEMBL15185472 | 0.80 | JAK2 (0.60) | JAK2JAK1JAK3 | |
| SCHEMBL15167188 | 0.80 | JAK2 (0.57) | JAK2JAK1JAK3 | |
| SCHEMBL15167186 | 0.80 | JAK2 (0.57) | JAK2JAK1JAK3 | |
| SCHEMBL18759722 | 0.80 | HDAC1 (0.49) | JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493895-B1 | N-CONTAINING HETEROARYL DERIVATIVES AS JAK3 KINASE INHIBITORS | VECTURA LTD (GB) | 2017-04-26 | — | — | EP | disclosed |