Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 16/20 | 0.59 |
| ▸ | KIT | P10721 | 3/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17325094 | 0.87 | ABL1 (0.64) | RETKITEGFRBRAF | |
| SCHEMBL18762351 | 0.87 | ABL1 (0.64) | RETKITEGFRBRAF | |
| SCHEMBL17325095 | 0.85 | RET (0.62) | RETKITEGFRBRAF | |
| SCHEMBL18762337 | 0.84 | KIT (0.75) | RETKIT | |
| SCHEMBL18762333 | 0.79 | RET (0.60) | RETKITEGFRBRAF | |
| SCHEMBL18775244 | 0.78 | ABL1 (0.52) | RETKITEGFRBRAF | |
| SCHEMBL18775248 | 0.78 | RET (0.51) | RETEGFRBRAF | |
| SCHEMBL17325101 | 0.76 | DDR2 (0.53) | RETKITEGFRBRAF | |
| SCHEMBL17325091 | 0.75 | ABL1 (0.82) | KIT | |
| SCHEMBL31620738 | 0.74 | ABL1 (0.66) | RETKITEGFRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170114057-A1 | 1H-1,8-NAPHTHYRIDIN-2ONES AS ANTI PROLIFERATIVE COMPOUNDS | NATCO PHARMA LIMITED (IN) | 2017-04-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114057-A1 | 1H-1,8-NAPHTHYRIDIN-2ONES AS ANTI PROLIFERATIVE COMPOUNDS | ABL1, MKI67, ABL2 | RET 503/4885KIT 34/4885EGFR 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.