Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 16/20 | 0.63 |
| ▸ | EGFR | P00533 | 9/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.63 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.63 |
| ▸ | KDR | P35968 | 6/20 | 0.60 |
| ▸ | RET | P07949 | 5/20 | 0.60 |
| ▸ | STK3 | Q13188 | 5/20 | 0.60 |
| ▸ | MAP4K5 | Q9Y4K4 | 5/20 | 0.60 |
| ▸ | CSF1R | P07333 | 4/20 | 0.60 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.60 |
| ▸ | FLT1 | P17948 | 3/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.59 |
| ▸ | LCK | P06239 | 4/20 | 0.59 |
| ▸ | FYN | P06241 | 4/20 | 0.59 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.59 |
| ▸ | INSR | P06213 | 4/20 | 0.59 |
| ▸ | AURKA | O14965 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1789889 | 0.94 | IGF1R (0.64) | IGF1REGFRERBB2PTK2CDK19 | |
| SCHEMBL1789532 | 0.94 | IGF1R (0.62) | IGF1REGFRERBB2PTK2CDK19 | |
| SCHEMBL1788382 | 0.92 | IGF1R (0.66) | IGF1REGFRERBB2PTK2CDK19 | |
| SCHEMBL1790035 | 0.91 | IGF1R (0.70) | IGF1REGFRERBB2PTK2CDK19 | |
| SCHEMBL1789122 | 0.90 | IGF1R (0.79) | IGF1REGFRERBB2PTK2CDK19 | |
| SCHEMBL1790678 | 0.90 | IGF1R (0.80) | IGF1REGFRERBB2PTK2CDK19 | |
| SCHEMBL1792604 | 0.89 | IGF1R (0.59) | IGF1REGFRERBB2PTK2CDK19 | |
| SCHEMBL1788249 | 0.89 | IGF1R (0.61) | IGF1REGFRERBB2PTK2CDK19 | |
| SCHEMBL1787813 | 0.88 | IGF1R (0.66) | IGF1REGFRERBB2PTK2CDK19 | |
| SCHEMBL1790603 | 0.88 | IGF1R (0.68) | IGF1REGFRERBB2PTK2CDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051315-B2 | Imidazopyridines as a novel scaffold for multi-targeted kinase inhibition | ABBVIE INC. (US) | 2015-06-09 | — | — | US | claimed |
| EP-2496574-A1 | IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION | Abbott Laboratories (US) | 2012-09-12 | — | — | EP | claimed |
| US-9051315-B2 | Imidazopyridines as a novel scaffold for multi-targeted kinase inhibition | ABBVIE INC. (US) | 2015-06-09 | — | — | US | disclosed |
| EP-2496574-A1 | IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION | Abbott Laboratories (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011053476-A1 | IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION | ABBOTT LABORATORIES (US) | 2011-05-05 | — | — | WO | disclosed |