Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 4/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1873543 | 0.93 | KDM4E (0.47) | KDM4EALDH1A1PIM1MAPK13GSK3A | |
| SCHEMBL1877954 | 0.91 | TLR8 (0.48) | KDM4EPIM1MAPK13GSK3AAKT1 | |
| SCHEMBL1881497 | 0.91 | TLR8 (0.45) | KDM4EPIM1MAPK13GSK3ADAPK3 | |
| SCHEMBL1874476 | 0.91 | KDM4E (0.45) | KDM4EPIM1MAPK13GSK3AGABRA1 | |
| SCHEMBL1877724 | 0.90 | TLR8 (0.44) | KDM4EPIM1MAPK13GSK3AAKT1 | |
| SCHEMBL1873926 | 0.90 | KDM4E (0.51) | KDM4EALDH1A1PIM1MAPK13GSK3A | |
| SCHEMBL10737443 | 0.87 | KDM4E (0.53) | KDM4EALDH1A1PIM1MAPK13GSK3A | |
| SCHEMBL1880200 | 0.86 | KDM4E (0.53) | KDM4EALDH1A1PIM1MAPK13GSK3A | |
| SCHEMBL1881246 | 0.85 | KDM4E (0.51) | KDM4EALDH1A1PIM1MAPK13GSK3A | |
| SCHEMBL1881418 | 0.85 | TLR8 (0.44) | KDM4EPIM1MAPK13GSK3ADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947688-B2 | N-[3-(3-substituted-pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-sulfonamides, and compositions, and methods related thereto | FERRER INTERNACIONAL, S.A. (ES) | 2011-05-24 | — | — | US | claimed |
| US-7947688-B2 | N-[3-(3-substituted-pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-sulfonamides, and compositions, and methods related thereto | FERRER INTERNACIONAL, S.A. (ES) | 2011-05-24 | — | — | US | disclosed |