Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 11/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9310615 | 0.87 | NPSR1 (0.57) | PANK3MEN1KMT2ASMN1; SMN2TRPV1 | |
| SCHEMBL388013 | 0.82 | TRPV1 (0.54) | PANK3MEN1KMT2ASMN1; SMN2TRPV1 | |
| SCHEMBL593040 | 0.81 | NPSR1 (0.51) | PANK3MEN1KMT2ASMN1; SMN2TRPV1 | |
| SCHEMBL3530997 | 0.79 | KIT (0.43) | MEN1KMT2ASMN1; SMN2HTTKIT | |
| SCHEMBL5646412 | 0.79 | MEN1 (0.52) | PANK3MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3532895 | 0.79 | KMT2A (0.45) | MEN1KMT2ASMN1; SMN2LMNAHTT | |
| SCHEMBL32675215 | 0.78 | PANK3 (0.74) | PANK3MEN1KMT2ASMN1; SMN2TRPV1 | |
| SCHEMBL21423990 | 0.78 | PANK3 (0.74) | PANK3MEN1KMT2ASMN1; SMN2TRPV1 | |
| SCHEMBL3531390 | 0.78 | TRPV1 (0.53) | TRPV1KIT | |
| SCHEMBL30778281 | 0.78 | TRPV1 (0.57) | PANK3MEN1KMT2ASMN1; SMN2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496557-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GlaxoSmithKline LLC (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011054841-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |