Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 6/20 | 0.41 |
| ▸ | LCK | P06239 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | TEK | Q02763 | 3/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18780263 | 0.78 | BTK (0.53) | BTKLCKSRCTEKGSTP1 | |
| SCHEMBL18800745 | 0.78 | BTK (0.43) | BTKLTA4HTNK2NPC1RAB9A | |
| SCHEMBL18780322 | 0.77 | BTK (0.53) | BTKTNK2GSTP1NPC1RAB9A | |
| SCHEMBL18780380 | 0.76 | BTK (0.54) | BTKGSTP1MEN1ALDH1A1KMT2A | |
| SCHEMBL18800753 | 0.76 | BTK (0.49) | BTKTNK2 | |
| SCHEMBL18780266 | 0.76 | BTK (0.53) | BTKLTA4HTNK2MEN1KMT2A | |
| SCHEMBL16168585 | 0.76 | BTK (0.53) | BTKTNK2LCKSRCTEK | |
| SCHEMBL18800492 | 0.75 | BTK (0.48) | BTKTNK2 | |
| SCHEMBL18800635 | 0.75 | BTK (0.48) | BTKTNK2 | |
| SCHEMBL16168567 | 0.75 | BTK (0.55) | BTKLTA4HTNK2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789614-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-04-26 | — | — | EP | disclosed |