Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 7/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22361506 | 0.83 | KCNA5 (0.43) | CYP1A2CYP2C19CYP3A4CYP2D6TSHR | |
| SCHEMBL8907960 | 0.81 | KCNA5 (0.59) | CYP1A2CYP2C19CYP3A4CYP2D6TSHR | |
| SCHEMBL10120875 | 0.81 | KCNA5 (0.59) | CYP1A2CYP2C19CYP3A4CYP2D6TSHR | |
| SCHEMBL11924817 | 0.79 | KCNA5 (0.57) | CYP1A2CYP2C19CYP3A4CYP2D6TSHR | |
| SCHEMBL8909027 | 0.79 | KCNA5 (0.57) | CYP1A2CYP2C19CYP3A4CYP2D6TSHR | |
| SCHEMBL19364542 | 0.78 | KCNA5 (0.41) | CYP1A2CYP2C19CYP3A4CYP2D6TSHR | |
| SCHEMBL9366790 | 0.76 | KCNA5 (0.55) | CYP1A2CYP2C19CYP3A4CYP2D6TSHR | |
| SCHEMBL11869847 | 0.74 | KCNA5 (0.48) | CYP1A2CYP2C19CYP3A4CYP2D6TSHR | |
| SCHEMBL31010334 | 0.73 | KCNA5 (0.57) | CYP1A2CYP2C19CYP3A4CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL7405456 | 0.71 | KCNA5 (0.55) | CYP1A2CYP2C19CYP3A4CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10017499-B2 | Benzimidazole derivatives | ENANTA PHARMACEUTICALS, INC. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170114046-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | ENANTA PHARM INC (US) | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114046-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | EIF2AK2, ZC3HAV1, HAVCR2 | CYP1A2 175/4885CYP2C19 180/4885CYP3A4 56/4885 |
| US-10017499-B2 | Benzimidazole derivatives | EIF2AK2, ZC3HAV1, ZC3HAV1L | CYP1A2 122/4885CYP2C19 105/4885CYP3A4 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.