Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 17/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2059008 | 0.88 | SMN1; SMN2 (0.38) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL2059010 | 0.88 | SMN1; SMN2 (0.38) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL12590877 | 0.88 | SMN1; SMN2 (0.44) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| Hydrochloric Acid SCHEMBL2058449 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| Hydrochloric Acid SCHEMBL2058446 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL12590978 | 0.82 | FLT3 (0.37) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL10235545 | 0.81 | HDAC1 (0.46) | SMN1; SMN2RAB9ANPC1TP53HTT | |
| SCHEMBL12590989 | 0.73 | SMN1; SMN2 (0.31) | SMN1; SMN2 | |
| SCHEMBL3638938 | 0.70 | HDAC6 (0.47) | SMN1; SMN2RAB9ANPC1HPGDMEN1 | |
| SCHEMBL10234239 | 0.68 | NPC1 (0.41) | SMN1; SMN2RAB9ANPC1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167489-B1 | PYRIMIDINE DERIVATIVES USEFUL AS RAF KINASE INHIBITORS | SUNESIS PHARMACEUTICALS INC (US) | 2017-05-03 | — | — | EP | disclosed |