Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 9/20 | 0.57 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | USP2 | O75604 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18789130 | 0.91 | MKNK2 (0.55) | MKNK2MKNK1KDM4EHKDC1CYP3A4 | |
| SCHEMBL18789181 | 0.86 | MKNK2 (0.54) | MKNK2MKNK1KDM4EHKDC1CYP3A4 | |
| SCHEMBL18789137 | 0.79 | MKNK2 (0.49) | MKNK2MKNK1CYP3A4USP2CYP1A2 | |
| SCHEMBL18789199 | 0.77 | MKNK2 (0.49) | MKNK2MKNK1KDM4EHKDC1CYP3A4 | |
| SCHEMBL18789123 | 0.77 | MKNK2 (0.55) | MKNK2MKNK1CYP3A4USP2CYP1A2 | |
| SCHEMBL18789219 | 0.76 | MKNK2 (0.56) | MKNK2MKNK1CYP3A4USP2CYP1A2 | |
| SCHEMBL18804757 | 0.75 | MKNK2 (0.61) | MKNK2MKNK1KDM4EHKDC1CYP3A4 | |
| SCHEMBL18789134 | 0.75 | MKNK2 (0.53) | MKNK2MKNK1KDM4EHKDC1CYP3A4 | |
| SCHEMBL18797852 | 0.75 | MKNK2 (0.47) | MKNK2MKNK1CYP3A4ALDH1A1ALOX15 | |
| SCHEMBL18789152 | 0.74 | MKNK2 (0.47) | MKNK2MKNK1KDM4EHKDC1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170121339-A1 | PYRROLO-, PYRAZOLO-, IMIDAZO-PYRIMIDINE AND PYRIDINE COMPOUNDS THAT INHIBIT MNK1 AND MNK2 | EFFECTOR THERAPEUTICS INC (US) | 2017-05-04 | — | — | US | disclosed |
| WO-2017075412-A1 | PYRROLO-, PYRAZOLO-, IMIDAZO-PYRIMIDINE AND PYRIDINE COMPOUNDS THAT INHIBIT MNK1 AND MNK2 | EFFECTOR THERAPEUTICS, INC. (US) | 2017-05-04 | — | — | WO | disclosed |
| US-20170121339-A1 | PYRROLO-, PYRAZOLO-, IMIDAZO-PYRIMIDINE AND PYRIDINE COMPOUNDS THAT INHIBIT MNK1 AND MNK2 | EFFECTOR THERAPEUTICS INC (US) | 2017-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170121339-A1 | PYRROLO-, PYRAZOLO-, IMIDAZO-PYRIMIDINE AND PYRIDINE COMPOUNDS THAT INHIBIT MNK1 AND MNK2 | NEK9, NEK2, TYK2 | MKNK2 38/4885MKNK1 67/4885KDM4E 2806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.