Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 5/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16738332 | 0.82 | BRD4 (0.49) | BRD4GPR119 | |
| SCHEMBL16738327 | 0.82 | BRD4 (0.51) | BRD4GSK3BDYRK1AWNT1RET | |
| SCHEMBL16738328 | 0.82 | BRD4 (0.51) | BRD4GSK3BDYRK1AWNT1RET | |
| SCHEMBL16738353 | 0.82 | BRD4 (0.54) | BRD4 | |
| SCHEMBL16738330 | 0.81 | BRD4 (0.45) | BRD4GPR119 | |
| SCHEMBL9932378 | 0.80 | BRD4 (0.56) | BRD4 | |
| SCHEMBL16738318 | 0.78 | BRD4 (0.47) | BRD4 | |
| SCHEMBL16738316 | 0.78 | BRD4 (0.47) | BRD4 | |
| SCHEMBL16738324 | 0.77 | BRD4 (0.45) | BRD4GSK3BDYRK1AWNT1RET | |
| SCHEMBL16738325 | 0.75 | BRD4 (0.41) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2859000-B1 | BENZO[C]ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2017-04-26 | — | — | EP | disclosed |